Juventus have suffered a double injury blow, with key defenders Leonardo Bonucci and Dani Alves both facing significant spells on the sidelines.
The duo were injured during the 3-1 weekend defeat at Genoa, with Italy centre-back Bonucci expected to be out of action for between 6-8 weeks due to a thigh problem.
The exact nature of Brazilian wing-back Alves' problem has yet to be determined, but Juve have confirmed that he has sustained a fracture to his left fibula.
A short statement from the club read: "Further medical examinations on Leonardo Bonucci have revealed the full extent of the injury which prematurely forced the defender from the field against Genoa on Sunday.
"Tests confirmed he is set to be on the sidelines for between 45 and 60 days after straining the biceps femoris muscle in his left thigh.
"Further details on Dani Alves, meanwhile, will arrive in the coming days – yesterday's initial prognosis established that the Brazilian had fractured his left fibula."
Despite their loss in Genoa on Sunday, Juve are still four points clear of the chasing pack in Serie A, with the Turin giants chasing a sixth consecutive Italian league title.
Roma and AC Milan are their closest rivals as things stand, with Lazio and Atalanta five points adrift of top spot.
Juve are available at 1/40 to win Lo Scudetto, with Milan priced at 4500/1 and Roma 16/1.
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