Borussia Dortmund captain Marco Reus will miss the first leg of their Champions League last-16 tie at Tottenham because of a thigh injury.
The 29-year-old Germany international has scored 17 goals in all competitions for the Bundesliga leaders this season.
However, he picked up the injury during last week's German Cup defeat to Werder Bremen and missed Saturday's 3-3 draw with Hoffenheim.
"We would, of course, have liked to have him in London, because his presence is a bit intimidating for the opponent," said Dortmund official Sebastian Kehl. "But we'll compensate for his absence."
It is unclear whether Reus will be fit enough to play in the return leg in Dortmund on 5th March.
Meanwhile, Spurs goalkeeper Hugo Lloris accepts that it will be difficult to get the better of Dortmund and reach the quarter-finals of the Champions League.
Mauricio Pochettino's team were fortunate to beat Leicester City 3-1 at Wembley on Sunday when not playing well while France international Lloris had to save Jamie Vardy's penalty and keep out an effort by Harvey Barnes with an outstretched leg.
"Dortmund play fantastic football with fantastic players and I'm not surprised they're top of the league in Germany," said Lloris.
"It's going to be very, very difficult. Some days it's difficult to deal with Wembley but, hopefully, in this big game, we'll receive help from the crowd.
"Leicester played fantastic and we won the game thanks to our spirit and character. Without that, we could not win. [But] we need to improve the team performance. Against a bigger side we couldn't have won that type of game. It's up to us."
Spurs can be backed at 21/20 to qualify for the last eight of the Champions League and at 8/1 to beat Dortmund 2-1 on Wednesday. Pochettino's team are 9/4 to keep a clean sheet in the first leg against the German side and 8/1 to win the Wembley clash from behind.