Gareth Bale has been ruled out of Wales' Nations League match against the Republic of Ireland and is returning to Read Madrid for treatment.
Bale has a groin injury which has ruled him out of recent Real Madrid games and also caused him to miss Wales' 4-1 defeat to Spain on Thursday.
Manager Ryan Giggs said after that game that Bale remained a doubt for Tuesday's match in Dublin and now the Football Association of Wales have confirmed that he will miss the game and return to his club.
Speaking after the Spain defeat Giggs confirmed he wanted to make a decision quickly on whether Bale would be available to face Martin O'Neill's side.
He said: "We'll make a decision in the next couple of days because then we have to prepare for the game.
"If Gareth is not available we have to prepare to see what team we're going to play, so we'll make it sooner rather than on the day."
Wales are 11/5 to win the game with the Republic of Ireland 6/4 and the draw is 19/10.
Ipswich winger Gwion Edwards has already been called up by the Welsh as possible cover for Bale.
He could make his first appearance for the Welsh senior side on Tuesday as could Sheffield United defender Kieron Freeman who has also been drafted in by Giggs with injury doubts surrounding Ethan Ampadu and Chris Mepham.
Tuesday night's game is the third for the Welsh in the Nations League. They are currently second in Group B after beating the Irish 4-1 at home but then losing 2-0 to Denmark.
Real meanwhile will hope to have Bale available as soon as possible after the international break as they face three big games in eight days; La Liga clashes against Levante and Barcelona with a Champions League clash against Viktoria Plzen in between.
Real Madrid are 11/4 to win La Liga with Barcelona 4/6.
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