Manchester City boss Pep Guardiola has confirmed that Aymeric Laporte and Fernandinho will be sidelined for several weeks after picking up injuries on Sunday.
Both players had to be substituted as City won the Carabao Cup final against Chelsea at Wembley 4-3 on penalties after the match had ended goalless after extra time.
City have the opportunity to win the quadruple as they are currently second in the Premier League table, after Liverpool drew 0-0 at Manchester United on Sunday, in control of their Champions League last-16 tie against Schalke and involved in the quarter-finals of the FA Cup next month.
Guardiola said after the Wembley win that City "will miss a lot of important players for a few weeks".
"Being in four competitions is so demanding, so tough, we don't know where we're going to arrive," he added. "Fernandinho and Laporte will be some weeks out."
Guardiola is also currently without injured duo John Stones and Benjamin Mendy while Nicolas Otamendi is suspended for the second leg against Schalke.
The former Barcelona and Bayern Munich manager admitted: "Winning this game is good for the enthusiasm for the next games. But we are going to suffer for the next competitions, especially in the Champions League and Premier League.
"But we will see how far we can go."
City are 1/6 to beat West Ham in the Premier League on Wednesday and 8/15 to win the Premier League title. They can be backed at 4/5 to win the FA Cup and at 11/4 to triumph in the Champions League for the first time in their history.